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The copper binding occurs through a specific square-planar pyramid configuration involving nitrogen atoms from histidine and glycine, plus a deprotonated amide nitrogen and carboxyl oxygen from lysine

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It is typically self-administered in an injectable form

The metabolic plasticity of cancer is not restricted only to cancer cells but extends throughout the TME (184, 185), as seen in CAFs that secrete lactate, lung mesenchymal-derived cells that transfer lipids, suppressing the functioning of NK cells, and arginine-depleting collagen-producing TAMs, leading to the suppression of CD8 + T cell functions