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Phase III trials of setmelanotide showed significant weight loss and hunger reduction in individuals with POMC and LEPR deficiency

Japan's PMDA often requires Japan-specific clinical data, which could delay approval there

Moreover, phosphorylation of mTOR at S2448 was enhanced by Exendin-4, confirming that GLP-1R signalling increases the activation state of mTOR, as previously demonstrated 16, 29, 30

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