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doi: 10.1007/s10555-011-9338-4 150 LiuLQiLKnifleyTPiecoroDWRychahouPLiuJet al

a BMI of 30 or higher with heart failure with preserved ejection fraction, uncontrolled high blood pressure, or moderate-to-advanced chronic kidney disease (stage 3a or higher)

The biological effects of activated 1,25(OH)D are mediated via its ligand-activated nuclear receptor, the VDR, which is broadly expressed across tissues and particularly enriched in skin cells