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In elaboration of these observations, work in an alpha-cell-specific PC1/3 knockout mouse model demonstrates that the loss of alpha-cell GLP-1 production impairs glucose homeostasis and GSIS in metabolically stressed mice but not in chow-fed mice (19)

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J Biol Chem (2013) 288(35):2508897.10.1074/jbc.M113.452516 194 EverardALazarevicVDerrienMGirardMMuccioliGGNeyrinckAMet alResponses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice