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Overall, our findings can contribute to guidance for rational GLP-1RA usage in Asia,suggesting that GLP-1 analogues are desirable for T2D patients with normal BMI as well as for those with overweight/obesity

12 Figure 16: PIONEER 2 closed testing procedure Source: Clinical Study Report

Caffeine is an adenosine analog and has been shown to confer neuroprotection against dopaminergic neurodegeneration via modulation of A 2A R pathways and neuroinflammation in PD models [64]