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In vivo, it has been observed that xenografts tumors are more resistant to FK866 treatment when NAPRT is upregulated, while they became more chemosensitive when NAPRT is silenced or inhibited

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doi: 10.1016/j.molbiopara.2005.08.018 225

Instead, discuss any changes in sexual function with your healthcare provider, who can assess contributing factors, adjust treatment if needed, or provide referrals to appropriate specialists for comprehensive management