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Selon la Harvard Medical School, les personnes prsentant un dficit en cobalamine peuvent ressentir des signes discrets mais progressifs, tels que des picotements ou un engourdissement, des difficults marcher, des troubles cognitifs ou de la mmoire, ainsi quune sensation de faiblesse

Participants were male and female adults aged 18 years who were of non-childbearing potential and met the BMI inclusion criteria of either 30.0 kg/m, or 27.0 kg/m with hypertension or dyslipidemia

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The barrier tightness of the model was verified by transendothelial electrical resistance (TEER) measurements using an EVOM voltohmmeter (World Precision Instruments, USA) combined with STX-2 electrodes