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*Correspondence: Raffaele Palmirotta [email protected] This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

They should never be utilized in research models involving active cancerous tumors, as angiogenesis can theoretically accelerate tumor growth by supplying blood to the malignant tissue