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When patients express interest in combining these substances, clinicians should conduct a thorough assessment including medical history, current medications, baseline kidney function, and treatment goals

With these assumptions, 1840 participants randomly assigned to semaglutide or placebo will provide 95% power to confirm superiority of semaglutide for the primary endpoint (change from baseline to week 104 in CDR-SB score)

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This is followed by mitogenic stimulation and measurement of DNA synthesis