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For individuals with type 2 diabetes and chronic kidney disease, semaglutide has been shown to slow the progression of kidney disease and lower the risk of kidney failure

Moreover, knockdown of PKC using an antisense oligonucleotide (ASO) protected rats from fat-induced hepatic insulin resistance [109], and PKC knockout mice ( Prkce / ) mice showed improved glucose tolerance than wild type controls after 7 days of high-fat feeding [118]

It is important to note that PDE5 inhibitors are contraindicated with nitrates and riociguat, and should be used with caution in patients taking alpha-blockers or those with unstable cardiovascular disease, as per BNF guidance

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