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Status: FDA-approved (metabolic/weight indications) Weekly SC injection Available via prescription Caveat: GLP-1 side effects including liver, kidney, and pancreatic risks are detectable early with proper lab monitoring

Kalyan Kumar Gangopadhyay has received speakership honorarium from Boehringer Ingelheim India, Astra Zeneca, Jansen, Novo Nordisk, and Eli Lilly

Through a systematic search of PubMed, Scopus, and Embase databases up to December 2023, ten randomized controlled trials (RCTs) involving 14,550 participants, with 7830 receiving semaglutide, were analyzed, with an additional number of 18 studies that were separately discussed because they reported data from the same RCTs

Enrichment of oral-derived bacteria in inflamed colorectal tumors and distinct associations of Fusobacterium in the mesenchymal subtype