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Infection and immunity 77 , 23672375 (2009)

Pharmacological treatment of the overweight patient

Direct growth hormone replacement has been explored as a longevity intervention, but it carries meaningful risks, including insulin resistance, fluid retention, carpal tunnel syndrome, and theoretical promotion of existing tumors, because GH and its primary mediator IGF-1 have potent pro-growth signaling that is indiscriminate about what it grows

This confirms the mechanism that depletion in total GSH and increase in GSSG in pyocyanin treated A549 cells is due to inhibition of GRed activity in pyocyanin treated cells ( Figure 9 )