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An unpublished clinical study has also associated a lacking responsiveness to GLP-1R agonist treatment ( liraglutide and exenatide ) with a higher presence of cardiovascular autonomic neuropathy ( Clinical Trial Registration Number: 7459 ) (Duvnajak et al., 2017)

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Angiotensin-converting enzyme-2 (ACE2) receptor plays a key role in the COVID-19 pathogenesis, while transmembrane protease, serine-2 (TMPRSS2) mediates priming of viral spike proteins with ACE2 [5]