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Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling

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31 , 32 This intestinal lactate is then transported to the liver where it contributes to gluconeogenesis in a form of gutliver crosstalk, promoting a splanchnic glucoselactateglucose cycle that may help regulate systemic glucose levels, despite its energetic inefficiency