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Despite this preclinical evidence, our pathway analysis reveals that the Neuroactive Ligand-Receptor Interaction Pathway does not directly integrate into the DM2-AD comorbidity network, supporting limited engagement with core diabetes-associated neurodegenerative mechanisms

The data confirmed that in patients undergoing HD, eryptosis levels are higher as compared with healthy individuals [261]

Research indicates that patients with Child-Pugh Class A cirrhosis (mild) often tolerate GLP-1 therapy with monitoring, while Class B and C (moderate to severe) carry elevated risk for hypoglycemia, drug accumulation, and worsening fluid retention

DeGregorio-Rocasolano, N