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10.1016/j.jmb.2019.08.009 J Mol Biol

PMID 34186022) 2 and body weight reductions of 15.0-20.9% across dose levels in obesity without diabetes (SURMOUNT-1

Intermittent use Some people use GLP-1 medications in cycles, perhaps 3 months on and 3 months off, or using the medication only during higher-risk periods (holidays, travel seasons, stressful life events)