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Manufacturing: A Peptide-Specific Bottleneck From a bioprocessing perspective, GLP-1 analogs present unique challenges due to their peptide nature: Peptide Stability: GLP-1 analogs are prone to degradation due to their sensitivity to temperate, pH and enzymatic activity

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That selectivity matters clinically: cortisol excess worsens hepatic gluconeogenesis and nitrogen wasting, risks that are already elevated in Child-Pugh B and C patients