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In L-cells of the lower intestine and colon the proprotein convertase subtilisin/kexin type 1 (or PCSK1/PC1) cleaves after single or double basic amino acids to liberate glicentin (amino acids 21-89 in proglucagon), oxyntomodulin (amino acids 53-89 in proglucagon), GLP-1 (amino acids 92-128 in proglucagon), and GLP-2 (amino acids 146-178 in proglucagon) (see UniProt P01275)

If you notice blood in your stools, significant unintentional weight loss beyond what is expected from the medication, or symptoms of anaemia such as extreme fatigue and pallor, these could indicate conditions requiring investigation beyond IBS and should be evaluated promptly

Boots In March 2026, Boots launched a free 12-month aftercare programme, which they describe as the first of its kind from an online healthcare provider in the UK