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The brand's FAQ explicitly states that people with medical conditions or taking prescription medications should consult their doctor before use - and for this specific product, the drug interaction profile of L-Arginine and L-Citrulline with nitrate medications, antihypertensives, and PDE5 inhibitors makes that recommendation more than standard legal boilerplate

11 The FDA removed BPC-157 from that interim list in April 2026, but for procedural reasons (withdrawn nominations and a renewed 503A review) rather than because those data gaps had been filled

The resulting pressure on blood vessels supplying the area decreases perfusion, causing ischaemia and hindering healing of the fissure

doi: 10.1002/ana.25455 264 WahrleS