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[30] [31] There is no evidence base for these combinations alongside an investigational agent

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Despite the varying results of numerous studies, owing to the alcohol's harmful and longlasting physical, mental, chemical, and behavioral implications, which cause a substantial financial burden on healthcare systems, most governments have deemed alcohol unsafe and taken steps to ensure that convenient access to alcohol is limited in line with the WHO action plan 20132020 (Burton & Sheron, 2018