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where S is the substrate (GSH), v is the reaction rate, k1 is the apparent first-order rate constant k1 was calculated based on the slope of fitted v -[ S ] curve

However, staying within the same anatomical region (e.g., alternating between abdomen sites rather than switching to thigh) may reduce absorption variability and improve dose predictability for patients with metabolic sensitivity to timing fluctuations

The effectiveness of desensitization versus rechallenge treatment in HIV-positive patients with previous hypersensitivity to TMP-SMX: a randomized multicentric study

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