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These effects can help clients reduce caloric intake, working alongside lifestyle changes such as diet and exercise to promote significant weight loss

12-13 Semaglutide and weight management Incorporating lifestyle factors such as diet and exercise is crucial when using semaglutide for weight loss

The preferential fat loss likely results from glucagon receptor activation, which increases resting energy expenditure and promotes fat oxidation as the primary fuel source, sparing protein catabolism for energy needs

"Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes"