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Lower tirzepatide doses (510mg weekly) reduce GI side effect burden while still providing meaningful appetite suppression, allowing researchers to maintain protocol adherence without the nausea and vomiting that causes 1015% of subjects to discontinue at higher doses

While facilities making compounded medications are strictly regulated for certain quality practices, the compounded medications themselves are not approved or evaluated by the FDA for safety, effectiveness, or quality

It's made in compounding pharmacies mostly because of the shortage of the drug

10.1016/j.molcel.2015.06.011 52 GaoS.-Q.LiuJ.-Q.HanY.-L.DejiQ.-Z.ZhabaW.-D.DengH.-J.et al (2020)