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Elevated CHOP disrupts apoptotic homeostasis by downregulating anti-apoptotic proteins (e.g., Bcl-2) and upregulating pro-apoptotic proteins (e.g., Bim), while simultaneously impairing the adaptive UPR, collectively driving dopaminergic neuron apoptosis in PD (18)

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[7] used electronic health records to analyze the components of diabetes-related costs (including costs of antidiabetics and of treating complications) in China, and found that of the total expenditure related to diabetes, 54% was spent on treating the cardiovascular complications of individuals with diabetes

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However, the lack of human trials, quick degradability of liposomes and safety concerns of soy lecithin (a liposomal component) are barriers against its current use

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