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Initially developed for diabetes, they are now widely used for obesity treatment and are under investigation for a wide range of other conditions, from kidney and heart disease to addiction to dementia

74,76,77 A pilot, open-label dose-ranging study involving 15 patients with cirrhosis and HE patients showed that oral GPB (6 mL) twice a day was tolerated and resulted in significant lowering of blood ammonia concentrations

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Specifically, 11 percent of patients with diabetes who took semaglutide developed NAOIN, while just 3 percent of patients with diabetes who took other medications developed the condition