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In a phase 3 trial, significantly more patients in the osilodrostat group had cortisol levels within normal limits (n = 37, 77.1%) than in the placebo group (n = 2, 8%) by week 12

It is crucial in the regulation of blood sugar and energy balance

Lyophilized powder tolerates brief ambient exposure better than reconstituted solution, but both degrade rapidly outside cold storage

These findings establish a consensus-driven and transferable computational framework for chemotype-diverse agonist discovery at conformationally flexible GPCR targets, and revealed a pentapeptide with GLP-1-like efficacy as a promising lead for next-generation small peptide therapeutics