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Like 7,8-DHF, the concentrations of O-methylated metabolites in plasma and brain did not appear to be affected by sex (Figure 7)

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5-Amino-1MQ is an orally bioavailable, cell-permeable small molecule that potently inhibits NNMT (nicotinamide N-methyltransferase), the enzyme responsible for methylating nicotinamide to 1-methylnicotinamide (1-MNA)