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The effects of SGLT2i on cardiac metabolism in patients with HFpEF: fact or fiction

The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

Differentiated cells express key hepatocyte markersincluding albumin, tyrosine aminotransferase (TAT), and cytokeratin-18 (CK18)at both the mRNA and protein levels and exhibit essential hepatocyte functions, such as albumin secretion, glycogen storage, and cytochrome P450 7A1 expression, thereby effectively mimicking the metabolic and detoxification functions of mature hepatocytes (Malik et al., 2018)

Gradinaru D, Borsa C, Ionescu C, Margina D, Prada GI, Jansen E