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Numerous pathways, including the GTP cyclohydrolase 1/tetrahydrobiopterin-phospholipid axis (98), the cystine/cysteine-GSH-peroxidase 4 (GPX4) axis (99,100), the ferroptosis suppressor protein 1-coenzyme Q (CoQ) 10 axis on the plasma membrane (101,102) and the mitochondrial dihydroorotate dehydrogenase/CoQ system, serve to counteract ferroptosis and maintain basal lipid peroxidation (103)
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The COMT connection: Another enzyme affected by poor methylation is COMT (catechol-O-methyltransferase), which breaks down and clears neurotransmitters like dopamine and adrenaline
Diabetes mellitus is another major contributor to CSVD
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