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In chronic pro-inflammatory conditions associated with alcohol use, drug intake, obesity, and diabetes, the generation of reactive oxygen species promotes liver damage and fibrosis, contributing to the onset and progression of ALD, alcoholic hepatitis, NAFLD, NASH, drug-induced liver toxicity, liver fibrosis, cirrhosis, and related complications

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And the failure rate is extremely high

Caroline Apovian, co-director of the Center for Weight Management and Wellness at Brigham and Womens Hospital in Boston