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The FDA-approved indications focus on glycemic control in type 2 diabetes and chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity, with some products (Wegovy, Saxenda) also approved for certain adolescents

This initial period is when the peptide begins to stimulate the cellular machinery, but the physical manifestation of increased melanin takes several weeks to become apparent

Severe reactions require immediate emergency medical attention and epinephrine administration