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Notably, SR18 occupied the same orthosteric binding pocket on both conformers of GLP-1R, a binding site typically occupied by GLP-1 and other similar peptide mimetics, as evidenced in reported structural studies (Zhang et al., 2017
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Consistent with these mechanisms, clinical studies indicate that peripheral pro-inflammatory cytokines in MDD, including granulocyte-macrophage colony-stimulating factor and interleukins IL-2, IL-4, and IL-6, are positively associated with mtDNA levels [40], supporting a link between mtDNA-related signaling and inflammatory dysregulation in depression
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