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Indeed, in the absence of bacteria, metformin shortened lifespan implying that it is the anti-bacterial action of metformin that explains the enhancement of lifespan in C

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Thus, we have demonstrated that GSH-targeted therapy selectively kills PC cells in an oxidative stress-dependent manner and that the differences in basal ROS level and antioxidant scavenging capacity induced by stratified expression of VRK2 can well account for the heterogeneous sensitivity to GSH inhibition