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Glp-l prepares the organism to receive carbohydrates by acting on four levels: Pre-warning the pancreatic beta cell so that it prepares itself to produce a sufficient amount of insulin Pre-warning the pancreatic alpha cell so that glucagon production is reduced and the liver stops releasing glucose into the blood Slowing down the digestion process so that the transit of carbohydrates in the intestine is gradual Activating the satiety centers in the brain, Glp-1 has a very short average life: a few tens of minutes, because quickly destroyed by the enzyme Dpp IV

10.1007/s00234-007-0243-z 264 Van RemmenH.IkenoY.HamiltonM.PahlavaniM.WolfN.ThorpeS