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This warning is based on rodent data , and the relevance to humans remains uncertain

Moreover, a randomized double-blind placebo-controlled clinical trial indicated that supplementation with Coenzyme Q10 (30 mg/day) and L-carnitine (500 mg/day) for 8 weeks had beneficial effects on migraine symptoms and serum levels of lactate (166)

Moreover, patients receiving the metabolic cofactors supplementation showed a greater magnitude of decrease in plasma level of downregulated cytokines compared with placebo group on Day 14