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A lack of energy can also disrupt these mechanisms

After FOXO4-DRI treatment, the staining of FOXO4 and p53-pS15 became weaker in the nucleus at 48 h and then disappeared with an accumulation in the cytoplasm at 72 h, especially in keloid fibroblasts

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Receptor-dependent effects of melatonin in CRC: Inhibition of adenylate cyclase, reduction of cAMP levels, activation of PLC, and modulation of mitochondrial signaling through intracellular MT1 receptors are among the receptor-dependent effects of melatonin in CRC