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Insulin resistance and metabolic dysfunction also play a major role

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Foodparticularly high-fat mealsdelays gastric emptying and prolongs intestinal transit time, which increases exposure to proteolytic enzymes and reduces the proportion of intact Dihexa that reaches the small intestine for absorption

The core loop of this molecular clock is driven by a heterodimeric transcriptional activator that is composed of two clock genes: circadian locomotor output cycle kaput (CLOCK) and brainmusclearnt-like protein 1 (BMAL1)