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Overall, 16 postmenopausal women were on hormone therapy, of whom 50% received transdermal estradiol 0.025 mg per day to 0.1 mg per day and 50% received daily oral estradiol 0.5 mg to 1 mg

As of Monday, Fitch had yet to receive a response.

While animal studies showed thyroid concerns in rodents, the MHRA and EMA have reviewed extensive human safety data without identifying thyroid function changes as a recognised adverse effect