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GSH, a critical intracellular antioxidant, lowers oxidative stress by neutralizing reactive oxygen species and restoring the antioxidant capacity of enzymes like glutathione peroxidase mechanisms that are severely disrupted in type 2 diabetes, where GSH levels are notably low and exacerbate insulin resistance, -cell dysfunction, nephropathy, retinopathy, and neuropathy

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The pairing is studied because the two compounds target repair through different but complementary mechanisms

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