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Its deficiency decreases -KG, impairing JMJD3/UTX demethylase activity, increasing H3K27me3, and promoting the expression of apoptosis inhibitors such as XIAP and survivin [104]

Vitamin B12 (cobalamin) supports red blood cell formation and normal nervous system function and acts as a co-factor in energy-related metabolism

In SURMOUNT trials, tirzepatide delivered up to 21% weight loss in adults without diabetes over 72 weeks

WesterterpMMurphyAJWangMPaglerTAVengrenyukYKappusMSet alDeficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice