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Furthermore, while human studies provide critical insights, animal models, particularly rodent models of T2D and obesity, offer valuable opportunities to explore the physiological, metabolic, and molecular responses to allulose in a controlled setting

Toxicological findings consistently indicate size- and shape-dependent uptake and effects: smaller particles exhibit greater cellular internalisation, reactivity, and biodistribution, with predominant oxidative, inflammatory, metabolic, and genotoxic responses, whereas larger microplastics more often provoke mechanical irritation

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Its important to note that individual responses can vary significantly, and factors such as dosage, timing, and individual physiology can play a role in the experienced effects