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Proteolysis of this protein by plasmin generates GHK [ 35 ]

Benefits remained after adjusting for diabetes, suggesting a possible direct anti-cancer effect

Conversely, caffeine slows this process, which may negate creatines benefits

Multiple sequence alignment analyses revealed that GSTO1-1 and GSTO2-2 contain a conserved catalytic cysteine residue and GSH binding sites, while other classes of GSTs have different amino acids in these positions, explaining why only GSTOs show DHAR activity 10,13