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Animal studies have shown a suppression of autophagy in activated microglia and infiltrating macrophages following TBI (Hegdekar et al., 2023)

44, e58558, 2022 Universidade Estadual de Maring Recepcin: 16 Abril 2021 Aprobacin: 09 Julio 2021 Abstract: Cardiovascular disease (CVD) remains the major cause of mortality in the world, typically claiming a third of all deaths

Physiological fatigue corresponds to a homeostatic process, selected by evolution for its usefulness, whereas pathological fatigue unravels a dyshomeostatic state, which reflects a combined dysfunctioning of numerous potential systems, revealed by both physiological issues (chronic inflammation, mitochondrial dysfunctioning, cardio-pulmonary pathologies, endocrinopathies, vitamin deficiencies) and interoceptive processes, with inappropriate corrections by the brain of biological perturbations

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