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Regarding the participants with MCI or AD, defined based on a clinical dementia rating (CDR) global score of 0.5 or 1, although the 18-month treatment with exenatide was safe and well-tolerated, it did not significantly affect clinical and cognitive measures, nor did it affect MRI cortical thickness and volume or most biomarkers in the cerebrospinal fluid (CSF), plasma, and plasma neuronal extracellular vesicles (EVs)

This multi-pathway approach has made it one of the most discussed compounds in current metabolic research, particularly in studies linked to weight management and blood glucose regulation

Binding of GLP-1 has been reported in the nucleus of the solitary tract (NTS) of the medulla oblongata as well

doi: 10.1007/s00125-014-3231-y