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ME1 and ME3 require NADP + and ME2 utilizes either NAD + or NADP + for their catalytic activities, thus NADPH can be produced by ME both directly and indirectly through the activity of the NNT that catalyzes the transfer of hydride ions from NADH to NADP + and produces NADPH in mitochondria

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B vitamins are also of interest for their ability to lower blood homocysteine levels, as high levels of homocysteine have been observed in a variety of diseases, including ADHD, and may contribute to oxidative stress

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