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Inhibiting ACSL4 expression reverses the inhibitory effect of interleukin-1 (IL-1) on collagen II (COL II) and aggrecan mRNA expression in chondrocytes, while alleviating IL-1s promoting effect on matrix metalloproteinase 13 (MMP13) mRNA expression (Sheng et al., 2024)

No intersection was detected between the targets of PFAS mixtures affecting hyperlipidemia and the targets of folate affecting hyperlipidemia

The association did not replicate in UK Biobank, although the expected power for replication in this cohort was low (Supplementary Table 11 and Supplementary Information)