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Furthermore, after acute UVB exposure, melanocytes in VDR-deficient mice exhibited reduced proliferative activity (PCNA/TYRP1), increased numbers of cells positive for the DNA damage marker CPD, and a significantly elevated apoptotic index (TUNEL/TYRP1), highlighting the protective role of VDR in mitigating UVB-induced genotoxic stress and sustaining melanocyte viability [134]

Glass vials for injection are not designed to be frozen

Leukemia Inhibitory Factor (LIF), a pro-inflammatory cytokine expressed in corticotrophs, has also been shown to stimulate POMC transcription via activation of the Jak-STAT pathway (35,36)