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Despite this, a substantial body of pre-clinical and limited clinical research has mapped DSIPs pharmacological effects across multiple systems, identifying several probable mechanistic axes including NMDA receptor modulation, adrenergic system regulation, MAPK/ERK cascade interaction, and mitochondrial respiration effects while acknowledging that the existence of an undiscovered DSIP-like endogenous peptide(s) may account for part of the DSIP-like immunoreactivity observed in tissue distribution studies

The core pathology of type 2 diabetes is insulin resistance and beta cell failure, which leads to imbalance of energy distribution: reduced glucose uptake by muscle and adipose tissue, increased gluconeogenesis in liver, and increased glucose and free fatty acid (FFA) levels in blood

Rare sugar D-psicose improves insulin sensitivity and glucose homeostasis in mice