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J Am Coll Cardiol 70(12):14291437 Sattar N, Lee MMY, Kristensen SL et al (2021) Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials

Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis

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Your genes largely determine how much melanin you produce, but sun exposure, hormones, and inflammation can also increase production and create darker spots or uneven tone