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Urgent research is required to identify synergistic combinations (e.g., FSP1 inhibitors with GPX4 inhibitors, ferroptosis inducers with IDO1/m6A inhibitors, and ferroptosis inducers with immune checkpoint blockade) that can simultaneously bypass multiple resistance pathways across diverse GBM subclones

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05 Dosage Accuracy: Use precise measurement tools to ensure accurate dosing

Monoamine oxidases (MAOs) a mitochondrially-located enzyme responsible for catalysing the oxidative deamination of H 2 O 2 85 is upregulated by the M2 macrophage-activating IL-13 and IL-4, or LPS signals